Rare diseases · Sign or symptom
Prolonged neonatal jaundice
Prolonged yellowing of skin in newborn
HP:0006579
What it means
Neonatal jaundice refers to a yellowing of the skin and other tissues of a newborn infant as a result of increased concentrations of bilirubin in the blood. Neonatal jaundice affects over half of all newborns to some extent in the first week of life. Prolonged neonatal jaundice is said to be present if the jaundice persists for longer than 14 days in term infants and 21 days in preterm infants.
Rare diseases that can present with this30
Very common80–99%
5Common30–79%
16- Alpha-1-antitrypsin deficiency
- Athyreosis
- Congenital bile acid synthesis defect type 2
- Congenital hypothyroidism due to maternal intake of antithyroid drugs
- Congenital isolated ACTH deficiency
- Familial thyroid dyshormonogenesis
- Hemolytic anemia due to red cell pyruvate kinase deficiency
- Hypothyroidism due to deficient transcription factors involved in pituitary development or function
- Hypothyroidism due to TSH receptor mutations
- Idiopathic congenital hypothyroidism
- Isolated biliary atresia
- Isolated thyroid-stimulating hormone deficiency
- Menkes disease
- Non-acquired isolated growth hormone deficiency
- Resistance to thyrotropin-releasing hormone syndrome
- Sotos syndrome
Sometimes5–29%
9- Aicardi-Goutières syndrome
- Allan-Herndon-Dudley syndrome
- Cerebrotendinous xanthomatosis
- Congenital hypothyroidism due to transplacental passage of TSH-binding inhibitory antibodies
- Congenital syphilis
- CTCF-related neurodevelopmental disorder
- Genetic transient congenital hypothyroidism
- Hereditary elliptocytosis
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Jaundice, neonatal · Neonatal jaundice
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.