Rare diseases · Sign or symptom
Ophthalmoparesis
Weakness of muscles controlling eye movement
HP:0000597
What it means
Ophthalmoplegia is a paralysis or weakness of one or more of the muscles that control eye movement.
Rare diseases that can present with this30
Very common80–99%
4Common30–79%
14- Atypical progressive supranuclear palsy syndrome
- Autosomal dominant progressive external ophthalmoplegia
- Dentatorubral pallidoluysian atrophy
- Giant cell arteritis
- Mitochondrial DNA-associated Leigh syndrome
- Mitochondrial DNA-related cardiomyopathy and hearing loss
- Mitochondrial neurogastrointestinal encephalomyopathy
- Myasthenia gravis
- Postsynaptic congenital myasthenic syndrome
- Sensory ataxic neuropathy-dysarthria-ophthalmoparesis syndrome
- Spinocerebellar ataxia type 28
- Spinocerebellar ataxia type 7
- Spinocerebellar ataxia with epilepsy
- Synaptic congenital myasthenic syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Extraocular muscle palsy · Extraocular muscle paralysis · Weakness of extraocular eye movement
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.