Rare diseases · Sign or symptom
Loss of ambulation
Loss of ability to walk
HP:0002505
What it means
Inability to walk in a person who previous had the ability to walk.
Rare diseases that can present with this33
Common30–79%
14- Atypical Rett syndrome
- Autosomal dominant adult-onset proximal spinal muscular atrophy
- Autosomal dominant spastic paraplegia type 9B
- Autosomal recessive Charcot-Marie-Tooth disease with hoarseness
- Autosomal recessive spastic paraplegia type 77
- Combined oxidative phosphorylation defect type 39
- Desminopathy
- Dystonia-parkinsonism-hypermanganesemia syndrome
- Fatty acid hydroxylase-associated neurodegeneration
- Late-infantile/juvenile Krabbe disease
- Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome
- Osteogenesis imperfecta
- Osteoporosis-pseudoglioma syndrome
- Plectin-related limb-girdle muscular dystrophy R17
Sometimes5–29%
16- Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
- Autosomal recessive axonal neuropathy with neuromyotonia
- Charcot-Marie-Tooth disease type 4G
- Choreoacanthocytosis
- Congenital muscular dystrophy with intellectual disability
- DNAJB6-related limb-girdle muscular dystrophy D1
- Familial infantile bilateral striatal necrosis
- HSD10 disease, infantile type
and 8 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.