Rare diseases · Sign or symptom
Abnormality of movement
Movement disorder
HP:0100022
What it means
An abnormality of movement with a neurological basis characterized by changes in coordination and speed of voluntary movements.
Movement disorders are characterized by the phenotypic abnormalities including abnormal involuntary movements, akathisia, akinesia, athetosis, ataxia, ballismus, bradykinesia, chorea, dyskinesia, dystonia, and myoclonus tics, tremor, spasms, and stereotypy.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this92
Very common80–99%
37- Ataxia-photosensitivity-short stature syndrome
- Ataxia-telangiectasia
- Atypical Rett syndrome
- Autosomal dominant striatal neurodegeneration
- Autosomal recessive malignant osteopetrosis
- Benign hereditary chorea
- Early-onset generalized limb-onset dystonia
- Early-onset parkinsonism-intellectual disability syndrome
- Encephalopathy due to sulfite oxidase deficiency
- Griscelli syndrome type 1
- Hereditary continuous muscle fiber activity
- Hereditary folate malabsorption
- Hereditary hyperekplexia
- HSD10 disease, atypical type
- Infant botulism
- Infantile-onset spinocerebellar ataxia
- Kennedy disease
- Leigh syndrome
- Lesch-Nyhan syndrome
- MERRF
- Methylmalonic acidemia with homocystinuria, type cblD
- Neonatal adrenoleukodystrophy
- Neuroectodermal melanolysosomal disease
- Neuronal intranuclear inclusion disease
- PEHO syndrome
- Pelizaeus-Merzbacher disease
- Porencephaly
- Primary orthostatic tremor
- Psychogenic movement disorders
- Sandhoff disease
- Severe microbrachycephaly-intellectual disability-athetoid cerebral palsy syndrome
- Sialidosis type 1
- Sialidosis type 2
- Spasmus nutans
- Tremor-nystagmus-duodenal ulcer syndrome
- WARS2-related combined oxidative phosphorylation defect
- Wieacker-Wolff syndrome
Common30–79%
35- 3-methylcrotonyl-CoA carboxylase deficiency
- Alpers-Huttenlocher syndrome
- Aniridia-cerebellar ataxia-intellectual disability syndrome
- Atypical juvenile parkinsonism
- Autosomal recessive multiple pterygium syndrome
- Autosomal recessive spastic paraplegia type 67
- Autosomal recessive spastic paraplegia type 69
- Autosomal recessive spastic paraplegia type 70
- Autosomal recessive spastic paraplegia type 71
- Bilateral generalized polymicrogyria
- Congenital lactic acidosis, Saguenay-Lac-Saint-Jean type
- Diencephalic syndrome
- Dysequilibrium syndrome
- Familial congenital mirror movements
- FOXG1 syndrome
- Gaucher disease
- GM1 gangliosidosis
- Guanidinoacetate methyltransferase deficiency
- Hepatic fibrosis-renal cysts-intellectual disability syndrome
- Huntington disease-like 2
- Isolated cerebellar agenesis
- Methylcobalamin deficiency type cblE
- Methylmalonic acidemia with homocystinuria
- Muscle-eye-brain disease
- Nasu-Hakola disease
- Neuhauser-Eichner-Opitz syndrome
- Niemann-Pick disease type C
- Oculocerebral hypopigmentation syndrome, Cross type
- Oxoglutaric aciduria
- Pseudo-TORCH syndrome type 1
- Recessive mitochondrial ataxia syndrome
- Spastic paraparesis-deafness syndrome
- Spinocerebellar ataxia type 34
- Sporadic infantile bilateral striatal necrosis
- TELO2-related intellectual disability-neurodevelopmental disorder
Sometimes5–29%
8The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Unusual movement
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.