Rare diseases · Sign or symptom
Hypertriglyceridemia
Increased plasma triglycerides
HP:0002155
What it means
An abnormal increase in the level of triglycerides in the blood.
Rare diseases that can present with this57
Always100%
3Very common80–99%
20- AKT2-related familial partial lipodystrophy
- Alström syndrome
- Atypical Werner syndrome
- Autosomal semi-dominant severe lipodystrophic laminopathy
- CIDEC-related familial partial lipodystrophy
- Dysbetalipoproteinemia
- Familial partial lipodystrophy, Dunnigan type
- Glycogen storage disease due to glucose-6-phosphatase deficiency type Ib
- Glycogen storage disease due to glycogen debranching enzyme deficiency
- Glycogen storage disease due to liver and muscle phosphorylase kinase deficiency
- Hypercholesterolemia due to cholesterol 7alpha-hydroxylase deficiency
- LCAT deficiency
- LIPE-related familial partial lipodystrophy
- LMNA-related cardiocutaneous progeria syndrome
- Lysosomal acid lipase deficiency
- Microcephalic primordial dwarfism-insulin resistance syndrome
- Neonatal intrahepatic cholestasis due to citrin deficiency
- PPARG-related familial partial lipodystrophy
- Tangier disease
- Xp21deletion syndrome
Common30–79%
24- Acquired hemophagocytic lymphohistiocytosis associated with malignant disease
- Autosomal dominant Emery-Dreifuss muscular dystrophy
- Autosomal recessive Emery-Dreifuss muscular dystrophy
- Bardet-Biedl syndrome
- Cholesteryl ester storage disease
- Chronic visceral acid sphingomyelinase deficiency
- Citrullinemia type II
- Congenital generalized lipodystrophy
- Emery-Dreifuss muscular dystrophy
- Familial hemophagocytic lymphohistiocytosis
- Glycogen storage disease due to liver phosphorylase kinase deficiency
- Hemophagocytic syndrome associated with an infection
- Idiopathic steroid-resistant nephrotic syndrome
- Lysinuric protein intolerance
- Macrophage activation syndrome
- Mandibuloacral dysplasia
- Neutral lipid storage disease with ichthyosis
- Neutral lipid storage disease with myopathy
- Obesity due to congenital leptin deficiency
- Obesity due to leptin receptor gene deficiency
- Progressive encephalopathy-severe neurodegeneration-lipodystrophy syndrome
- Smith-Magenis syndrome
- Wiedemann-Rautenstrauch syndrome
- X-linked Emery-Dreifuss muscular dystrophy
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Increased circulating Tg levels · Increased plasma Tg levels · Increased serum triglycerides · Increased triglycerides
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.