Rare diseases · Sign or symptom
Hyperlipidemia
Elevated lipids in blood
HP:0003077
What it means
An elevated lipid concentration in the blood.
Hyperlipidemia is an elevation of the blood levels of lipids including primarily cholesterol, phospholipids and triglycerides and cholesterol esters. The lipids are transported on lipoproteins some of which are commonly used for clinical measurements, including chylomicrons, very-low density lipoproteins (VLDL), intermediate-density lipoproteins (IDL), low-density lipoproteins, and high-density lipoproteins (HDL).
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this34
Very common80–99%
8- Alström syndrome
- Aromatase deficiency
- Cholestasis-lymphedema syndrome
- Glycogen storage disease due to glucose-6-phosphatase deficiency
- Glycogen storage disease due to glucose-6-phosphatase deficiency type Ib
- Microtriplication 11q24.1 syndrome
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- Woodhouse-Sakati syndrome
Common30–79%
17- Carnitine palmitoyltransferase II deficiency
- Carnitine palmitoyl transferase II deficiency, neonatal form
- Chronic visceral acid sphingomyelinase deficiency
- Citrullinemia type II
- Congenital analbuminemia
- Cushing syndrome due to bilateral macronodular adrenocortical disease
- Fabry disease
- Griscelli syndrome type 1
- Griscelli syndrome type 2
- Heme oxygenase-1 deficiency
- Idiopathic steroid-sensitive nephrotic syndrome with secondary steroid resistance
- Mandibuloacral dysplasia with type A lipodystrophy
- Mandibuloacral dysplasia with type B lipodystrophy
- Methanol poisoning
- Parenteral nutrition-associated cholestasis
- Primary triglyceride deposit cardiomyovasculopathy
- Schimke immuno-osseous dysplasia
Sometimes5–29%
5The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 2 diseases where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.