Rare diseases · Sign or symptom
Exercise intolerance
Decreased ability to exercise
HP:0003546
What it means
A functional motor deficit where individuals whose responses to the challenges of exercise fail to achieve levels considered normal for their age and gender.
Rare diseases that can present with this54
Very common80–99%
8- Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
- Becker muscular dystrophy
- Carnitine palmitoyl transferase II deficiency, myopathic form
- Eisenmenger syndrome
- Glycogen storage disease due to muscle beta-enolase deficiency
- Glycogen storage disease due to muscle glycogen phosphorylase deficiency
- Mitochondrial trifunctional protein deficiency
- Pure mitochondrial myopathy
Common30–79%
29- Absence of the pulmonary artery
- Asbestos intoxication
- Atrial septal defect, coronary sinus type
- Atrial septal defect, ostium secundum type
- Atrial septal defect, sinus venosus type
- Autosomal dominant mitochondrial myopathy with exercise intolerance
- Autosomal dominant progressive external ophthalmoplegia
- Autosomal recessive ataxia due to ubiquinone deficiency
- Autosomal recessive axonal neuropathy with neuromyotonia
- Barth syndrome
- Carnitine palmitoyltransferase II deficiency
- Carnitine palmitoyl transferase II deficiency, severe infantile form
- Childhood-onset nemaline myopathy
- Craniofaciofrontodigital syndrome
- Fabry disease
- Glycogen storage disease due to acid maltase deficiency
- Glycogen storage disease due to muscle and heart glycogen synthase deficiency
- Glycogen storage disease due to muscle phosphorylase kinase deficiency
- Glycogen storage disease due to phosphoglycerate mutase deficiency
- Hereditary atrial fibrillation
- High altitude pulmonary edema
- Hyperprolinemia type 2
- Mitochondrial DNA-related cardiomyopathy and hearing loss
- Myopathy and diabetes mellitus
- Osteogenesis imperfecta
- Poliomyelitis
- Progressive external ophthalmoplegia-myopathy-emaciation syndrome
- Southeast Asian ovalocytosis
- TK2-related mitochondrial DNA maintenance defect, myopathic form
Sometimes5–29%
17- Atrial septal defect, ostium primum type
- Autosomal recessive progressive external ophthalmoplegia
- Bronchopulmonary dysplasia
- Congenital heart block
- Glutaryl-CoA dehydrogenase deficiency
- Glycogen storage disease due to liver and muscle phosphorylase kinase deficiency
- Glycogen storage disease due to liver phosphorylase kinase deficiency
- GMPPB-related limb-girdle muscular dystrophy R19
and 9 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Inability to exercise · Low exercise endurance · Poor exercise tolerance
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.