Rare diseases · Sign or symptom
Bilateral single transverse palmar creases
HP:0007598
What it means
The distal and proximal transverse palmar creases are merged into a single transverse palmar crease on both hands.
Rare diseases that can present with this71
Very common80–99%
18- Acromesomelic dysplasia, Hunter-Thompson type
- Aplasia cutis congenita-intestinal lymphangiectasia syndrome
- Ataxia-photosensitivity-short stature syndrome
- Distal deletion 17q syndrome
- Distal monosomy 7q36 syndrome
- Fibular aplasia-complex brachydactyly syndrome
- Lethal faciocardiomelic dysplasia
- Microbrachycephaly-ptosis-cleft lip syndrome
- Microcephalic osteodysplastic primordial dwarfism types I and III
- Microlissencephaly-micromelia syndrome
- Non-distal deletion 10q syndrome
- Penoscrotal transposition
- Severe microbrachycephaly-intellectual disability-athetoid cerebral palsy syndrome
- Sheldon-Hall syndrome
- Trisomy 13 syndrome
- X-linked intellectual disability-hypogammaglobulinemia-progressive neurological deterioration syndrome
- XY type gonadal dysgenesis-associated anomalies syndrome
- Zellweger-like syndrome without peroxisomal anomalies
Common30–79%
33- 16p11.2p12.2microdeletion syndrome
- 2q37microdeletion syndrome
- Acrofacial dysostosis, Catania type
- Anonychia-microcephaly syndrome
- Blepharophimosis-intellectual disability syndrome, SBBYS type
- Böök syndrome
- Cleft lip/palate-ectodermal dysplasia syndrome
- Cleidorhizomelic syndrome
- Conductive deafness-ptosis-skeletal anomalies syndrome
- Cornelia de Lange syndrome
- Cryptorchidism-arachnodactyly-intellectual disability syndrome
- C syndrome
- Distal deletion 10p syndrome
- Distal duplication 18q syndrome
- Down syndrome
- Extrasystoles-short stature-hyperpigmentation-microcephaly syndrome
- Fetal trimethadione syndrome
- Filippi syndrome
- Intellectual disability-spasticity-ectrodactyly syndrome
- Maternal hyperthermia-induced birth defects
- McDonough syndrome
- Microcephaly-cardiac defect-lung malsegmentation syndrome
- Microphthalmia with limb anomalies
- Mosaic trisomy 14 syndrome
- Multiple synostoses syndrome
- Neonatal adrenoleukodystrophy
- Prolidase deficiency
- Prominent glabella-microcephaly-hypogenitalism syndrome
- Recombinant 8 syndrome
- Roifman syndrome
- Saethre-Chotzen syndrome
- Trisomy 18 syndrome
- Trisomy 9p syndrome
Sometimes5–29%
20- 11q22.2q22.3microdeletion syndrome
- 14q22q23microdeletion syndrome
- 17q23.1q23.2microdeletion syndrome
- 2p15p16.1microdeletion syndrome
- Autosomal recessive Robinow syndrome
- Craniofacial dysplasia-short stature-ectodermal anomalies-intellectual disability syndrome
- External auditory canal atresia-vertical talus-hypertelorism syndrome
- Laurence-Moon syndrome
and 12 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.