Myelodysplastic neoplasm with low blasts

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Myelodysplastic neoplasm with low blasts

ORPHA:98826Disease

Also called MDS-LB · Refractory anemia

What it is

Refractory cytopenias with unilineage dysplasia (RCUD) is a frequent low-risk subtype of myelodysplastic syndrome (MDS) characterized by refractory cytopenias associated with dysplasia limited to one cell lineage.

Key facts

Age of onset
Adolescent, Adult, Childhood, Elderly, Infancy
Inheritance
Not applicable
Classified as
Disease

Recorded for the broader condition

Prevalence
<1 / 1 000 000 (annual incidence, Europe)Refractory cytopenia with multilineage dysplasia

Orphanet records these for the broader condition rather than for this specific form. They are a starting point, not a figure for this subtype — subtypes often differ, and some are defined by being rarer than the condition they sit under.

Signs and symptoms

These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.

Gene

TET2Disease-causing somatic mutation(s)

ICD-10 codes

D46.7filed under a broader ICD-10 category — shared with 6 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

MEDDRA 10038269MESH D000753MONDO 0005272MONDO 5272UMLS C2981142

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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