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Start free with EleplanAcrofacial dysostosis, Weyers type
ORPHA:952Malformation syndrome
Also called Curry-Hall syndrome · Weyers acrodental dysostosis · Weyers acrofacial dysostosis
What it is
A rare ectodermal dysplasia syndrome with bone abnormalities characterized by onychodystrophy; anomalies of the lower jaw, oral vestibule and dentition; post-axialpolydactyly; moderately restricted growth with short limbs; and normal intelligence. Although it closely resembles Ellis-van Creveld syndrome, an allelic disorder and another type of ciliopathy, WAD is usually a milder disease without the presence of heart abnormalities and is inherited in an autosomal dominant manner.
Key facts
- Age of onset
- Neonatal
- Inheritance
- Autosomal dominant
- Classified as
- Malformation syndrome
Recorded for the broader condition
- Prevalence
- 6-9 / 10 000Ectodermal dysplasia syndrome
Orphanet records these for the broader condition rather than for this specific form. They are a starting point, not a figure for this subtype — subtypes often differ, and some are defined by being rarer than the condition they sit under.
Signs and symptoms
Very common80–99%
14- Abnormal fingernail morphology
- Abnormality of the dentition
- Abnormal oral frenulum morphology
- Abnormal toenail morphology
- Advanced eruption of teeth
- Conical tooth
- Hypodontia
- Hypoplastic toenails
- Mild short stature
- Nail dystrophy
- Postaxial hand polydactyly
- Single median maxillary incisor
- Small nail
- Toenail dysplasia
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Genes
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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