I21

Non-billable

Acute myocardial infarction

I21 is the ICD-10-CM code for Acute myocardial infarction. It is a non-billable category code — use a more specific child code such as I21.0 for billing.

Status
Header (non-billable)
Chapter
I00-I99
Subcodes
8
Edition
FY2026

I00-I99 Diseases of the circulatory system

Includes

  • cardiac infarction
  • coronary (artery) embolism
  • coronary (artery) occlusion
  • coronary (artery) rupture
  • coronary (artery) thrombosis
  • infarction of heart, myocardium, or ventricle
  • myocardial infarction specified as acute or with a stated duration of 4 weeks (28 days) or less from onset

Excludes2 — not included here

  • old myocardial infarction (I25.2)
  • postmyocardial infarction syndrome (I24.1)
  • subsequent type 1 myocardial infarction (I22.-)

Use additional code

  • code, if applicable, to identify:
  • exposure to environmental tobacco smoke (Z77.22)
  • history of tobacco dependence (Z87.891)
  • occupational exposure to environmental tobacco smoke (Z57.31)
  • status post administration of tPA (rtPA) in a different facility within the last 24 hours prior to admission to current facility (Z92.82)
  • tobacco dependence (F17.-)
  • tobacco use (Z72.0)

Frequently asked questions

What is ICD-10 code I21?
I21 is the ICD-10-CM code for "Acute myocardial infarction". It falls under I00-I99 Diseases of the circulatory system.
Is I21 a billable code?
No — I21 is a non-billable header code. Use a more specific child code (such as I21.0) for billing.
What are the subcodes of I21?
I21 has 8 more specific child codes, including I21.0, I21.1, I21.2.

Source: CMS ICD-10-CM FY2026. For informational purposes only — not medical advice. See our medical disclaimer.

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