Rare diseases · Sign or symptom
Thick vermilion border
Full lips
HP:0012471
What it means
Increased width of the skin of vermilion border region of upper lip.
Rare diseases that can present with this68
Very common80–99%
14- Aspartylglucosaminuria
- Atkin-Flaitz syndrome
- Cantú syndrome
- Char syndrome
- CHIME syndrome
- Encephalopathy due to sulfite oxidase deficiency
- Frank-Ter Haar syndrome
- Hall-Riggs syndrome
- Hypohidrotic ectodermal dysplasia
- MEHMO syndrome
- Neu-Laxova syndrome
- Pitt-Hopkins syndrome
- Progressive spondyloepimetaphyseal dysplasia-short stature-short fourth metatarsals-intellectual disability syndrome
- Spinocerebellar ataxia-dysmorphism syndrome
Common30–79%
29- 19p13.3microduplication syndrome
- 1q41q42microdeletion syndrome
- 6q terminal deletion syndrome
- Acromegaly
- Alazami syndrome
- Alpha-N-acetylgalactosaminidase deficiency type 2
- Alport syndrome-intellectual disability-midface hypoplasia-elliptocytosis syndrome
- Aphonia-deafness-retinal dystrophy-bifid halluces-intellectual disability syndrome
- Birk-Barel syndrome
- CDKL5-deficiency disorder
- Craniosynostosis-anal anomalies-porokeratosis syndrome
- FG syndrome type 1
- FOXP1 Syndrome
- FRAXE intellectual disability
- Hemifacial hyperplasia
- Hurler syndrome
- Hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome
- Lenz-Majewski hyperostotic dysplasia
- Microcephalic osteodysplastic primordial dwarfism types I and III
- Mucopolysaccharidosis type 2
- Ptosis-upper ocular movement limitation-absence of lacrimal punctum syndrome
- Recombinant 8 syndrome
- Ring chromosome 22 syndrome
- Scheie syndrome
- Tall stature-intellectual disability-renal anomalies syndrome
- Temple-Baraitser syndrome
- X-linked intellectual disability, Wilson type
- Xq25microduplication syndrome
- XYLT1-CDG
Sometimes5–29%
24- 16q24.3microdeletion syndrome
- 21q22.11q22.12microdeletion syndrome
- 8p23.1duplication syndrome
- Alpha-N-acetylgalactosaminidase deficiency
- Autosomal dominant hypohidrotic ectodermal dysplasia
- Craniofaciofrontodigital syndrome
- Distal 22q11.2 microduplication syndrome
- Donohue syndrome
and 16 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Increased volume of lip · Increased volume of lip vermillion · Plump lips · Prominent lips · Thick lips
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.