Rare diseases · Sign or symptom
Squamous cell carcinoma
HP:0002860
What it means
The presence of squamous cell carcinoma of the skin.
Rare diseases that can present with this27
Common30–79%
3Sometimes5–29%
13- Combined immunodeficiency due to DOCK8 deficiency
- Disseminated superficial actinic porokeratosis
- Hereditary acrokeratotic poikiloderma
- Hyperkeratosis lenticularis perstans
- Inherited epidermodysplasia verruciformis
- Kindler epidermolysis bullosa
- NTHL1-related polyposis
- Papillon-Lefèvre syndrome
and 5 more in this range
Rare1–4%
10- Acquired hemophagocytic lymphohistiocytosis associated with malignant disease
- Autosomal recessive generalized dystrophic epidermolysis bullosa, intermediate form
- Chromomycosis
- Congenital erythropoietic porphyria
- KID syndrome
- Necrobiosis lipoidica
- Punctate palmoplantar keratoderma type 1
- Recurrent respiratory papillomatosis
and 2 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 5 diseases where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Squamous cell cancer
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.