Rare diseases · Sign or symptom
Spastic tetraparesis
HP:0001285
What it means
Spastic weakness affecting all four limbs.
Rare diseases that can present with this33
Very common80–99%
4Common30–79%
14- Autosomal recessive spastic paraplegia type 35
- Bilateral frontal polymicrogyria
- Bilateral polymicrogyria
- Craniosynostosis-hydrocephalus-Arnold-Chiari malformation type I-radioulnar synostosis syndrome
- Familial infantile bilateral striatal necrosis
- Fatty acyl-CoA reductase 1 deficiency
- FBLN1-related developmental delay-central nervous system anomaly-syndactyly syndrome
- ITM2B amyloidosis
- Keppen-Lubinsky syndrome
- L-2-hydroxyglutaric aciduria
- Pelizaeus-Merzbacher disease, classic form
- Pelizaeus-Merzbacher disease, transitional form
- PLA2G6-related neurodegeneration, infantile-onset
- X-linked intellectual disability-limb spasticity-retinal dystrophy-arginine vasopressin deficiency
Sometimes5–29%
15- 3-methylglutaconic aciduria type 1
- 9q33.3q34.11microdeletion syndrome
- ALG3-CDG
- Autosomal dominant spastic paraplegia type 31
- Dyggve-Melchior-Clausen disease
- Early-onset progressive encephalopathy-spastic ataxia-distal spinal muscular atrophy syndrome
- Folinic acid-responsive seizures
- HSD10 disease, infantile type
and 7 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Spastic quadriparesis
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.