Rare diseases · Sign or symptom
Sparse eyebrow
Sparse eyebrows
HP:0045075
What it means
Decreased density/number of eyebrow hairs.
Sparseness can be regional (medial, central, lateral) or total.
Rare diseases that can present with this60
Very common80–99%
24- 8q22.1microdeletion syndrome
- Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
- Autosomal dominant palmoplantar keratoderma and congenital alopecia
- Cartilage-hair hypoplasia
- Cerebellar-facial-dental syndrome
- Cerebello-oculo-facio-genital syndrome
- CHST3-related skeletal dysplasia
- Craniofacial dysplasia-short stature-ectodermal anomalies-intellectual disability syndrome
- EEC syndrome
- Flat face-microstomia-ear anomaly syndrome
- Focal facial dermal dysplasia type II
- GAPO syndrome
- Hypohidrotic ectodermal dysplasia-hypothyroidism-ciliary dyskinesia syndrome
- Hypotrichosis simplex
- Megalencephaly-severe kyphoscoliosis-overgrowth syndrome
- Neonatal ichthyosis-sclerosing cholangitis syndrome
- Netherton syndrome
- Odonto-onycho dysplasia-alopecia syndrome
- Pallister-Killian syndrome
- Proximal 16p11.2 microduplication syndrome
- Pseudoprogeria syndrome
- Restrictive dermopathy
- Trichodysplasia-xeroderma syndrome
- Trichorhinophalangeal syndrome type 1
Common30–79%
18- 2q37microdeletion syndrome
- Alazami syndrome
- B4GALT7-related spondylodysplastic Ehlers-Danlos syndrome
- Basel-Vanagaite-Smirin-Yosef syndrome
- Bazex-Dupré-Christol syndrome
- Cerebrooculonasal syndrome
- Craniofrontonasal dysplasia-Poland anomaly syndrome
- Frontonasal dysplasia-severe microphthalmia-severe facial clefting syndrome
- Hallermann-Streiff syndrome
- Hidrotic ectodermal dysplasia
- Keratosis follicularis spinulosa decalvans
- KID syndrome
- Nasopalpebral lipoma-coloboma syndrome
- Primary hypergonadotropic hypogonadism-partial alopecia syndrome
- Rothmund-Thomson syndrome
- Visceral neuropathy-brain anomalies-facial dysmorphism-developmental delay syndrome
- Xq25microduplication syndrome
- Yunis-Varon syndrome
Sometimes5–29%
17- 17q11.2microduplication syndrome
- 2p15p16.1microdeletion syndrome
- Early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome
- Gabriele-de Vries syndrome
- Global developmental delay-alopecia-macrocephaly-facial dysmorphism-structural brain anomalies syndrome
- Goldberg-Shprintzen megacolon syndrome
- Ichthyosis-alopecia-eclabion-ectropion-intellectual disability syndrome
- Incontinentia pigmenti
and 9 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hypotrichosis of eyebrow
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.