Rare diseases · Sign or symptom
Premature graying of hair
Early graying
HP:0002216
What it means
Development of gray hair at a younger than normal age.
Rare diseases that can present with this26
Very common80–99%
16- Ataxia-telangiectasia
- Atypical Werner syndrome
- Autosomal semi-dominant severe lipodystrophic laminopathy
- Böök syndrome
- Griscelli syndrome
- Griscelli syndrome type 1
- Griscelli syndrome type 2
- LMNA-related cardiocutaneous progeria syndrome
- Microcephalic primordial dwarfism, Montreal type
- Neuroectodermal melanolysosomal disease
- Sensorineural hearing loss-early graying-essential tremor syndrome
- Vogt-Koyanagi-Harada disease
- Waardenburg-Shah syndrome
- Waardenburg syndrome
- Waardenburg syndrome type 2
- Werner syndrome
Common30–79%
6- Branchio-oculo-facial syndrome
- Hoyeraal-Hreidarsson syndrome
- Lipodystrophy due to peptidic growth factors deficiency
- Moyamoya angiopathy-short stature-facial dysmorphism-hypergonadotropic hypogonadism syndrome
- Peripheral demyelinating neuropathy-central dysmyelinating leukodystrophy-Waardenburg syndrome-Hirschsprung disease
- Waardenburg syndrome type 1
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Early greying · Premature graying · Premature graying of the hair · Premature greying · Premature greying of hair · Premature greying of the hair · Premature hair graying · Premature hair greying
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.