Rare diseases · Sign or symptom
Papule
HP:0200034
What it means
A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point.
Rare diseases that can present with this74
Very common80–99%
43- Alpha-N-acetylgalactosaminidase deficiency type 2
- Behçet disease
- Benign cephalic histiocytosis
- Blau syndrome
- Body skin hyperlaxity due to vitamin K-dependent coagulation factor deficiency
- Bullous lichen planus
- CINCA syndrome
- Cowden syndrome
- Cutaneous mastocytosis-deafness-microtia syndrome
- Cutaneous small vessel vasculitis
- Elastoderma
- Erythrokeratoderma ''en cocardes''
- Familial anetoderma
- Familial cutaneous collagenoma
- Familial keratoacanthoma
- Familial multiple trichoepithelioma
- Hereditary acrokeratotic poikiloderma
- Hyperkeratosis-hyperpigmentation syndrome
- Hyperkeratosis lenticularis perstans
- Ichthyosis follicularis-alopecia-photophobia syndrome
- Inherited epidermodysplasia verruciformis
- Interstitial granulomatous dermatitis with arthritis
- Jessner lymphocytic infiltration of the skin
- Juvenile hyaline fibromatosis
- Leishmaniasis
- Lhermitte-Duclos disease
- Lichen amyloidosis
- Lichen planopilaris
- Linear IgA dermatosis
- Lipoid proteinosis
- Majeed syndrome
- Malakoplakia
- Malignant atrophic papulosis
- Pityriasis rubra pilaris
- Progressive nodular histiocytosis
- Prolidase deficiency
- Pseudoxanthoma elasticum-like skin manifestations with retinitis pigmentosa
- Pyoderma gangrenosum
- Schnitzler syndrome
- Scleromyxedema
- Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome
- Spinocerebellar ataxia type 34
- Syringocystadenoma papilliferum
Common30–79%
14- 17q11microdeletion syndrome
- Acquired ichthyosis
- Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
- Chronic mucocutaneous candidiasis
- Dermatomyositis
- Diffuse palmoplantar keratoderma, Bothnian type
- Epidermolysis bullosa simplex with muscular dystrophy
- Familial multiple nevi flammei
- Generalized eruptive keratoacanthoma
- Granulomatosis with polyangiitis
- Hyperimmunoglobulinemia D with periodic fever
- Kaposi sarcoma
- Leukoencephalopathy-palmoplantar keratoderma syndrome
- Necrobiosis lipoidica
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Papules · Skin papules
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.