Rare diseases · Sign or symptom
Oligohydramnios
Low levels of amniotic fluid
HP:0001562
What it means
Diminished amniotic fluid volume in pregnancy.
Oligohydramnios is the opposite of polyhydramnios. In normal pregnancy the amniotic fluid volume increases by about 10 ml/day until the 34th, after which it slowly diminishes. A normal amniotic fluid volume at term is about 500-2,000 ml. Oligohydramnios is defined as an AFI (amniotic fluid index) less than 5 cm or smallest vertical pocket of fluid less than 2 cm.
Rare diseases that can present with this82
Very common80–99%
12- Absent radius-anogenital anomalies syndrome
- Axial mesodermal dysplasia spectrum
- Campomelia, Cumming type
- Holzgreve syndrome
- Hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome
- Lethal hemolytic anemia-genital anomalies syndrome
- Orofaciodigital syndrome type 4
- Paternal uniparental disomy of chromosome 6 syndrome
- Penile agenesis
- Renal agenesis, bilateral
- Thomas syndrome
- TMEM70-related mitochondrial encephalo-cardio-myopathy
Common30–79%
24- 46,XX difference of sex development-anorectal anomalies syndrome
- Acro-renal-mandibular syndrome
- Aphalangy-hemivertebrae-urogenital-intestinal dysgenesis syndrome
- Atresia of urethra
- Autosomal recessive polycystic kidney disease
- Craniosynostosis, Herrmann-Opitz type
- Frontonasal dysplasia-alopecia-genital anomalies syndrome
- Hemoglobin Bart's fetalis syndrome
- Maternal uniparental disomy of chromosome 20 syndrome
- Maternal uniparental disomy of chromosome 2 syndrome
- Meckel syndrome
- Mosaic trisomy 2 syndrome
- Mosaic trisomy 9 syndrome
- NPHP3-related Meckel-like syndrome
- Paternal 20q13.2q13.3 microdeletion syndrome
- Pierson syndrome
- Prune belly syndrome
- Renal-hepatic-pancreatic dysplasia
- Renal hypoplasia, bilateral
- Ring chromosome 2 syndrome
- Silver-Russell syndrome due to 11p15 microduplication
- Silver-Russell syndrome due to a point mutation
- Stüve-Wiedemann syndrome
- Ulbright-Hodes syndrome
Sometimes5–29%
40- 17q12microdeletion syndrome
- 20q13.33microdeletion syndrome
- 8q24.3microdeletion syndrome
- ALG8-CDG
- ALG9-CDG
- Arthrogryposis-renal dysfunction-cholestasis syndrome
- B3GALT6-related spondylodysplastic Ehlers-Danlos syndrome
- Blepharophimosis-intellectual disability syndrome, Verloes type
and 32 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased amniotic fluid index · Maternal oligohydramnios
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.