Rare diseases · Sign or symptom
Intrinsic hand muscle atrophy
HP:0008954
What it means
Atrophy of the intrinsic muscle groups of the hand, comprising the thenar and hypothenar muscles; the interossei muscles; and the lumbrical muscles.
Rare diseases that can present with this18
Very common80–99%
3Common30–79%
10- Adult-onset distal myopathy due to VCP mutation
- Autosomal recessive Charcot-Marie-Tooth disease with hoarseness
- Charcot-Marie-Tooth disease-deafness-intellectual disability syndrome
- Distal myopathy, Tateyama type
- HNRNPA1-related adult-onset distal myopathy
- KLHL9-related early-onset distal myopathy
- Late-onset distal myopathy, Markesbery-Griggs type
- Moderate multiminicore disease with hand involvement
- X-linked Charcot-Marie-Tooth disease type 2
- X-linked Charcot-Marie-Tooth disease type 3
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.