Rare diseases · Sign or symptom
Hyperlordosis
Prominent swayback
HP:0003307
What it means
Abnormally increased curvature (anterior concavity) of the lumbar or cervical spine.
Rare diseases that can present with this71
Very common80–99%
12- Absence deformity of leg-cataract syndrome
- Camptodactyly-joint contractures-facial skeletal defects syndrome
- Cartilage-hair hypoplasia
- Facioscapulohumeral dystrophy
- Hereditary sensory and autonomic neuropathy type 2
- Inclusion body myopathy with Paget disease of bone and frontotemporal dementia
- Intellectual disability-myopathy-short stature-endocrine defect syndrome
- Metaphyseal chondrodysplasia, Spahr type
- Microcephaly-cervical spine fusion anomalies syndrome
- Rhizomelic dysplasia, Patterson-Lowry type
- Satoyoshi syndrome
- Thoracomelic dysplasia
Common30–79%
28- 3MC syndrome
- 3M syndrome
- Acrocapitofemoral dysplasia
- Acromesomelic dysplasia, Maroteaux type
- Alpha-sarcoglycan-related limb-girdle muscular dystrophy R3
- Atherosclerosis-deafness-diabetes-epilepsy-nephropathy syndrome
- Autosomal dominant spondylocostal dysostosis
- Calpain-3-related limb-girdle muscular dystrophy R1
- Cataract-intellectual disability-hypogonadism syndrome
- Combined immunodeficiency with facio-oculo-skeletal anomalies
- Congenital muscular dystrophy due to LMNA mutation
- Craniofacial dysostosis-diaphyseal hyperplasia syndrome
- Deafness-epiphyseal dysplasia-short stature syndrome
- DNA2-related mitochondrial DNA deletion syndrome
- GM1 gangliosidosis
- Iniencephaly
- Isolated glycerol kinase deficiency
- Microbrachycephaly-ptosis-cleft lip syndrome
- Mucolipidosis type III
- Mucopolysaccharidosis type 4
- Progressive spondyloepimetaphyseal dysplasia-short stature-short fourth metatarsals-intellectual disability syndrome
- Rigid spine syndrome
- Saethre-Chotzen syndrome
- Schwartz-Jampel syndrome
- TRAPPC11-related limb-girdle muscular dystrophy R18
- Trichodermodysplasia-dental alterations syndrome
- Trichorhinophalangeal syndrome type 1
- Williams syndrome
Sometimes5–29%
29- Alexander disease
- Autosomal dominant Emery-Dreifuss muscular dystrophy
- Autosomal recessive centronuclear myopathy
- Autosomal recessive Emery-Dreifuss muscular dystrophy
- BICD2-related autosomal dominant childhood-onset proximal spinal muscular atrophy
- Camurati-Engelmann disease
- Cleft lip/palate-ectodermal dysplasia syndrome
- Congenital fiber-type disproportion myopathy
and 21 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Lordosis
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.