Rare diseases · Sign or symptom
Depressed nasal ridge
Flat nose
HP:0000457
What it means
Lack of prominence of the nose resulting from a posteriorly-placed nasal ridge.
The adjective 'depressed' here does not indicate an active process but a status. The feature should be assessed in a profile view. This finding is typically associated with a Short columella, but this should be assessed separately.
Rare diseases that can present with this65
Very common80–99%
28- 8q22.1microdeletion syndrome
- Acrocephalopolydactyly
- Acrodysostosis
- Char syndrome
- CHIME syndrome
- Cleft lip/palate-deafness-sacral lipoma syndrome
- Congenital heart defect-round face-developmental delay syndrome
- Craniofacial-deafness-hand syndrome
- Craniofrontonasal dysplasia
- Delayed membranous cranial ossification
- Dysmorphism-pectus carinatum-joint laxity syndrome
- Familial osteodysplasia, Anderson type
- Fetal hydantoin syndrome
- Fetal valproate spectrum disorder
- Focal facial dermal dysplasia type III
- Freeman-Sheldon syndrome
- Frontofacionasal dysplasia
- GM1 gangliosidosis
- Harlequin ichthyosis
- Hypertelorism-hypospadias-polysyndactyly syndrome
- Leukomelanoderma-infantilism-intellectual disability-hypodontia-hypotrichosis syndrome
- Maxillonasal dysplasia
- Orofaciodigital syndrome type 4
- Osteosclerotic bone dysplasia
- Renal agenesis, bilateral
- Rhizomelic dysplasia, Patterson-Lowry type
- X-linked dominant chondrodysplasia, Chassaing-Lacombe type
- X-linked hypohidrotic ectodermal dysplasia
Common30–79%
26- 1p36deletion syndrome
- 22q11.2duplication syndrome
- 48,XXXY syndrome
- Alobar holoprosencephaly
- Auricular abnormalities-cleft lip with or without cleft palate-ocular abnormalities syndrome
- Brachytelephalangic chondrodysplasia punctata
- Carpenter syndrome
- Combined pituitary hormone deficiencies, genetic forms
- Dislocation of the hip-dysmorphism syndrome
- Down syndrome
- Holoprosencephaly
- Laurin-Sandrow syndrome
- Lethal hemolytic anemia-genital anomalies syndrome
- Lobar holoprosencephaly
- Meckel syndrome
- Midline interhemispheric variant of holoprosencephaly
- Neu-Laxova syndrome
- Non-acquired panhypopituitarism
- Pallister-Hall syndrome
- Prolidase deficiency
- Pyknoachondrogenesis
- Semilobar holoprosencephaly
- Short stature-brachydactyly-obesity-global developmental delay syndrome
- Stickler syndrome
- Thoracic dysplasia-hydrocephalus syndrome
- X-linked alpha-thalassemia-intellectual disability syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Depressed dorsum of nose · Depressed nasal dorsum · Flat dorsum of nose · Flat nasal dorsum · Recessed dorsum of nose · Recessed nasal dorsum · Recessed nasal ridge · Retruded dorsum of nose
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.