Rare diseases · Sign or symptom
Corpus callosum atrophy
HP:0007371
What it means
The presence of atrophy (wasting) of the corpus callosum.
Rare diseases that can present with this11
Very common80–99%
1Common30–79%
3Sometimes5–29%
6- 19p13.13microdeletion syndrome
- Autosomal dominant spastic paraplegia type 9A
- Autosomal recessive cerebellar ataxia due to STUB1 deficiency
- Autosomal recessive spastic paraplegia type 9B
- Combined oxidative phosphorylation defect type 39
- Severe motor and intellectual disabilities-sensorineural deafness-dystonia syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Atrophic corpus callosum · Atrophy of the corpus callosum · Atrophy/Degeneration of the corpus callosum
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.