Fetal and neonatal alloimmune…

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Fetal and neonatal alloimmune thrombocytopenia

ORPHA:853Disease

Also called FNAIT · NAIT

What it is

A rare hematological disease characterized by maternal alloimmunisation against fetal platelet antigens that are inherited from the father and different from those present in the mother, and usually presents as a severe isolated thrombocytopenia in otherwise healthy newborns.

Key facts

Prevalence
1-5 / 10 000
Age of onset
Antenatal, Neonatal
Inheritance
Not applicable
Classified as
Disease

Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.

Signs and symptoms

These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.

Genes

ITGB3Major susceptibility factor
CD109Candidate gene tested
GP1BACandidate gene tested
GP1BBCandidate gene tested
ITGA2Candidate gene tested
ITGA2BCandidate gene tested

ICD-10 codes

P61.0filed under a broader ICD-10 category

Cross-references

GARD 2295MONDO 0019415UMLS C3854603

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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