Autosomal recessive distal renal tubular…

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Autosomal recessive distal renal tubular acidosis

ORPHA:402041Clinical subtype

Also called AR dRTA · Autosomal recessive distal RTA

What it is

A rare autosomal recessive form of proximal renal tubular acidosis (pRTA) characterized by an isolated defect in the proximal tubule leading to the decreased reabsorption of bicarbonate and consequently causing urinary bicarbonate wastage. Mild growth retardation and reduced bone density are extra-renal complications. Several fractures and delayed puberty are possible features.

Key facts

Age of onset
Childhood, Infancy
Inheritance
Autosomal recessive
Classified as
Clinical subtype

Genes

ATP6V0A4Disease-causing germline mutation(s)
ATP6V1B1Disease-causing germline mutation(s)
FOXI1Disease-causing germline mutation(s)
WDR72Disease-causing germline mutation(s)

ICD-10 codes

N25.8filed under a broader ICD-10 category — shared with 17 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Benefit programs to look at

Programs whose eligibility touches the same ICD-10 categories. Eligibility is decided by the administering agency, never by this page.

Cross-references

GARD 4666MESH C537758MONDO 0018440OMIM 267300OMIM 602722UMLS C1864498

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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