Transient familial neonatal…

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Transient familial neonatal hyperbilirubinemia

ORPHA:2312Disease

Also called Lucey-Driscoll syndrome

What it is

A rare genetic hepatic disease characterized by very high serum bilirubin levels in a newborn, clinically presenting as jaundice during the first few days of life. The condition is usually self-resolving, although in some cases it can lead to kernicterus with corresponding symptoms (including lethargy, high-pitched crying, hypotonia, missing reflexes, vomiting, or seizures, among others), which may result in chronic disability and even death.

Key facts

Age of onset
Neonatal
Classified as
Disease

Gene

UGT1A1Candidate gene tested

ICD-10 codes

P59.8filed under a broader ICD-10 category

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

GARD 2791MESH C562692MONDO 0009383OMIM 237900UMLS C0270210

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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