Tessier number 7 facial cleft

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Tessier number 7 facial cleft

ORPHA:141276Morphological anomaly

Also called Commissural facial cleft · Transverse facial cleft

What it is

A rare lateral facial cleft characterized by a temporo-zygomatic defect, usually with absence of the zygomatic arch and deformities of the mandibular ramus, condyle, and coronoid process. Associated soft tissue abnormalities include malformations of the ear and hypoplasia or absence of the temporal muscle. Preauricular hair may be absent or divided into two portions. Facial manifestations include macrostomia (with extension of the cleft to the corner of the mouth) and pre-auricular tags. Incomplete clefts may be found in the molar region and between the maxillary tuberosity and pterygoid process.

Key facts

Age of onset
Antenatal, Neonatal
Inheritance
Autosomal dominant
Classified as
Morphological anomaly

Genes

PTCH2Disease-causing germline mutation(s)
SPECC1LDisease-causing germline mutation(s)

ICD-10 codes

Q18.4filed under a broader ICD-10 category

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

MONDO 0013300OMIM 613545UMLS C4552111

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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