Syndromic congenital sodium diarrhea

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Syndromic congenital sodium diarrhea

ORPHA:563708Disease

Also called Syndromic congenital tufting enteropathy

What it is

A rare, genetic, syndromic intestinal disorder, characterized by congenital onset of severe watery diarrhea containing high concentrations of sodium, hyponatremia and metabolic acidosis, and generally, uni- or bilateral choanal atresia, and corneal erosions. Additional congenital malformations may include intestinal atresia, and hexadactyly.

Key facts

Age of onset
Antenatal, Neonatal
Inheritance
Autosomal recessive
Classified as
Disease

Gene

SPINT2Disease-causing germline mutation(s) (loss of function)

ICD-10 codes

K59.8filed under a broader ICD-10 category — shared with 5 other rare diseases
K90.8filed under a broader ICD-10 category — shared with 5 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

MONDO 0034204OMIM 270420UMLS C5680120

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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