Rare diseases · Sign or symptom
Spastic paraparesis
HP:0002313
What it means
Partial loss of the ability to move the lower limbs accompanied by spasticity of the lower limbs.
Rare diseases that can present with this38
Very common80–99%
4Common30–79%
14- 3-methylglutaconic aciduria type 3
- Alexander disease type II
- Alpers-Huttenlocher syndrome
- Autosomal recessive spastic paraplegia type 20
- Autosomal recessive spastic paraplegia type 55
- Beta-propeller protein-associated neurodegeneration
- Combined oxidative phosphorylation defect type 7
- Early-onset spastic ataxia-myoclonic epilepsy-neuropathy syndrome
- Homocystinuria due to methylene tetrahydrofolate reductase deficiency
- Krabbe disease
- Late-infantile/juvenile Krabbe disease
- Mitochondrial membrane protein-associated neurodegeneration
- Oculodentodigital dysplasia
- Spinocerebellar ataxia type 40
Sometimes5–29%
17- Aicardi-Goutières syndrome
- Amyotrophic lateral sclerosis
- Biotinidase deficiency
- Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome
- Developmental delay-facial dysmorphism syndrome due to MED13L deficiency
- Eales disease
- Hurler syndrome
- Intellectual disability-balding-patella luxation-acromicria syndrome
and 9 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.