Rare diseases · Sign or symptom
Skin erosion
HP:0200041
What it means
A discontinuity of the skin exhibiting incomplete loss of the epidermis, a lesion that is moist, circumscribed, and usually depressed.
Rare diseases that can present with this34
Very common80–99%
7Common30–79%
17- Autosomal recessive generalized dystrophic epidermolysis bullosa, intermediate form
- Autosomal recessive generalized epidermolysis bullosa simplex
- Congenital erythropoietic porphyria
- Diffuse cutaneous mastocytosis
- Epidermolysis bullosa simplex with pyloric atresia
- Erosive pustular dermatosis of the scalp
- Focal dermal hypoplasia
- Graft versus host disease
- Hepatoerythropoietic porphyria
- IgA pemphigus
- Laryngo-onycho-cutaneous syndrome
- Meige disease
- Pemphigus foliaceus
- Pemphigus vegetans
- PLEC-related intermediate epidermolysis bullosa simplex without extracutaneous involvement
- Variegate porphyria
- Vulvovaginal gingival syndrome
Sometimes5–29%
9- Acral peeling skin syndrome
- Autosomal dominant generalized dystrophic epidermolysis bullosa
- Cutaneous mastocytoma
- Fixed drug eruption
- Kikuchi-Fujimoto disease
- Localized dystrophic epidermolysis bullosa, pretibial form
- Localized epidermolysis bullosa simplex
- Pemphigus erythematosus
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.