Rare diseases · Sign or symptom
Progressive spasticity
HP:0002191
What it means
Spasticity that increases in degree with time.
Rare diseases that can present with this16
Very common80–99%
5Common30–79%
10- Alpers-Huttenlocher syndrome
- Autosomal recessive spastic paraplegia type 32
- Coffin-Lowry syndrome
- Early-onset progressive diffuse brain atrophy-microcephaly-muscle weakness-optic atrophy syndrome
- Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome
- Maternal uniparental disomy of chromosome 1 syndrome
- Metachromatic leukodystrophy
- NKX6-2-related autosomal recessive hypomyelinating leukodystrophy
- PLA2G6-related neurodegeneration, infantile-onset
- X-linked intellectual disability, Seemanova type
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Spasticity, progressive
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.