Rare diseases · Sign or symptom
Progressive spastic paraplegia
HP:0007020
Rare diseases that can present with this33
Always100%
2Very common80–99%
17- Autosomal dominant spastic paraplegia type 12
- Autosomal dominant spastic paraplegia type 19
- Autosomal dominant spastic paraplegia type 36
- Autosomal dominant spastic paraplegia type 37
- Autosomal dominant spastic paraplegia type 38
- Autosomal dominant spastic paraplegia type 41
- Autosomal dominant spastic paraplegia type 42
- Autosomal dominant spastic paraplegia type 73
- Autosomal dominant spastic paraplegia type 8
- Autosomal recessive spastic paraplegia type 48
- Autosomal recessive spastic paraplegia type 74
- Autosomal recessive spastic paraplegia type 78
- Autosomal spastic paraplegia type 30
- Fatty acid hydroxylase-associated neurodegeneration
- MT-ATP6-related mitochondrial spastic paraplegia
- Severe intellectual disability and progressive spastic paraplegia
- Spastic paraplegia-severe developmental delay-epilepsy syndrome
Common30–79%
14- 8p inverted duplication/deletion syndrome
- Autosomal recessive spastic paraplegia type 32
- Autosomal recessive spastic paraplegia type 66
- Autosomal recessive spastic paraplegia type 67
- Autosomal recessive spastic paraplegia type 69
- Autosomal recessive spastic paraplegia type 70
- Autosomal recessive spastic paraplegia type 71
- Kyphoscoliosis-lateral tongue atrophy-hereditary spastic paraplegia syndrome
- Mutilating hereditary sensory neuropathy with spastic paraplegia
- Null syndrome
- Spastic paraplegia-intellectual disability-nystagmus-obesity syndrome
- Spastic paraplegia-neuropathy-poikiloderma syndrome
- Spastic paraplegia-optic atrophy-neuropathy syndrome
- Spastic paraplegia-precocious puberty syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Progressive spastic paraplegia
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.