Rare diseases · Sign or symptom
Progressive muscle weakness
HP:0003323
Rare diseases that can present with this15
Very common80–99%
8- Congenital fiber-type disproportion myopathy
- Desminopathy
- Distal anoctaminopathy
- Duchenne muscular dystrophy
- Facioscapulohumeral dystrophy
- Glycogen storage disease due to muscle phosphorylase kinase deficiency
- Infantile Refsum disease
- TBCK-related encephalopathy-severe hypotonia-craniofacial dysmorphism syndrome
Common30–79%
4The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Muscle weakness, progressive · Progressive muscular weakness
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.