Rare diseases · Sign or symptom
Non-midline cleft of the upper lip
HP:0100335
What it means
Clefting (gap or groove) of the upper lip affecting the lateral portions of the upper lip rather than the midline/median region.
Rare diseases that can present with this41
Very common80–99%
10- Acrofrontofacionasal dysostosis
- Alar cartilages hypoplasia-coloboma-telecanthus syndrome
- Charlie M syndrome
- Cleft lip/palate-deafness-sacral lipoma syndrome
- Contractures-ectodermal dysplasia-cleft lip/palate syndrome
- Dysraphism-cleft lip/palate-limb reduction defects syndrome
- Frontofacionasal dysplasia
- Genitopalatocardiac syndrome
- Hartsfield syndrome
- Verloove Vanhorick-Brubakk syndrome
Common30–79%
18- Aminopterin/methotrexate embryofetopathy
- Anophthalmia plus syndrome
- Autosomal dominant popliteal pterygium syndrome
- Blepharonasofacial malformation syndrome
- Branchio-oculo-facial syndrome
- Congenital laryngomalacia
- Diprosopus
- Distal monosomy 7q36 syndrome
- Fetal alcohol syndrome
- Fryns syndrome
- Intellectual disability, Wolff type
- Isolated cleft lip
- Postaxial acrofacial dysostosis
- Tetraamelia-multiple malformations syndrome
- Triploidy syndrome
- Trisomy 18 syndrome
- Trisomy 8q syndrome
- XY type gonadal dysgenesis-associated anomalies syndrome
Sometimes5–29%
13- Ankyloblepharon filiforme adnatum-cleft palate syndrome
- Ankyloblepharon filiforme adnatum-imperforate anus syndrome
- Distal deletion 10p syndrome
- Nager syndrome
- Nijmegen breakage syndrome
- Oculoauriculovertebral spectrum with radial defects
- Oculodentodigital dysplasia
- Orofaciodigital syndrome type 5
and 5 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Paramedian cleft of the upper lip
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.