Rare diseases · Sign or symptom
Motor axonal neuropathy
HP:0007002
What it means
Progressive impairment of function of motor axons with muscle weakness, atrophy, and cramps. The deficits are length-dependent, meaning that muscles innervated by the longest nerves are affected first, so that for instance the arms are affected at a later age than the onset of deficits involving the lower leg.
Distal motor neuropathy is a bundled term that should not be used if more detailed information about the phenotype is available.
Rare diseases that can present with this21
Very common80–99%
3Common30–79%
8- Autosomal dominant Charcot-Marie-Tooth disease type 2W
- Autosomal dominant Charcot-Marie-Tooth disease type 2Z
- Autosomal recessive axonal neuropathy with neuromyotonia
- Autosomal recessive spastic paraplegia type 39
- Autosomal recessive spastic paraplegia type 60
- Infantile-onset axonal motor and sensory neuropathy-optic atrophy-neurodegenerative syndrome
- Mitochondrial membrane protein-associated neurodegeneration
- Polyneuropathy associated with IgM monoclonal gammopathy
Sometimes5–29%
8The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Distal motor neuropathy · Length dependent motor neuropathy
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.