Rare diseases · Sign or symptom
Lower limb amyotrophy
HP:0007210
What it means
Muscular atrophy affecting the lower limb.
Rare diseases that can present with this18
Very common80–99%
3Common30–79%
13- Adenylosuccinate synthetase-like 1-related distal myopathy
- Anoctamin-5-related limb-girdle muscular dystrophy R12
- Autosomal dominant spastic paraplegia type 12
- Autosomal dominant spastic paraplegia type 19
- Autosomal dominant spastic paraplegia type 41
- Autosomal dominant spastic paraplegia type 42
- Autosomal recessive spastic paraplegia type 5A
- Autosomal recessive spastic paraplegia type 66
- Autosomal recessive spastic paraplegia type 77
- Charcot-Marie-Tooth disease type 4D
- Charcot-Marie-Tooth disease type 4G
- Kyphoscoliosis-lateral tongue atrophy-hereditary spastic paraplegia syndrome
- Ocular anomalies-axonal neuropathy-developmental delay syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Lower limb amyotrophy
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.