Rare diseases · Sign or symptom
Hepatic fibrosis
HP:0001395
What it means
The presence of excessive fibrous connective tissue in the liver. Fibrosis is a reparative or reactive process.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this37
Very common80–99%
4Common30–79%
12- Acute infantile liver failure-cerebellar ataxia-peripheral sensory motor neuropathy syndrome
- Alpha-1-antitrypsin deficiency
- Dietary iron overload disease
- FADD-related immunodeficiency
- Glycogen storage disease due to liver and muscle phosphorylase kinase deficiency
- Glycogen storage disease due to liver phosphorylase kinase deficiency
- Growth delay-intellectual disability-hepatopathy syndrome
- PLIN1-related familial partial lipodystrophy
- Primary biliary cholangitis
- Primary sclerosing cholangitis
- Senior-Boichis syndrome
- Trichohepatoenteric syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Liver fibrosis
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.