Rare diseases · Sign or symptom
Hemolytic anemia
HP:0001878
What it means
A type of anemia caused by premature destruction of red blood cells (hemolysis).
Normally, erythrocytes survive on average about 110-120 days. With hemolysis, the erythrocyte survival is shortened, and generally increased marrow activity results in a reticulocyte count.
Rare diseases that can present with this39
Very common80–99%
13- 8p11.2deletion syndrome
- Babesiosis
- Cold agglutinin disease
- Dehydrated hereditary stomatocytosis
- Glutathione synthetase deficiency
- HELLP syndrome
- Heme oxygenase-1 deficiency
- Infection-related hemolytic uremic syndrome
- Nijmegen breakage syndrome
- Overhydrated hereditary stomatocytosis
- Paroxysmal nocturnal hemoglobinuria
- Rh deficiency syndrome
- Sickle cell anemia
Common30–79%
10- Acute bilirubin encephalopathy
- Autoimmune hemolytic anemia-autoimmune thrombocytopenia-primary immunodeficiency syndrome due to TPP2 deficiency
- Chronic bilirubin encephalopathy
- Glycogen storage disease due to aldolase A deficiency
- Glycogen storage disease due to phosphoglycerate kinase 1 deficiency
- LCAT deficiency
- Sitosterolemia
- Southeast Asian ovalocytosis
- Wilson disease
- Wiskott-Aldrich syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Haemolytic anaemia · Haemolytic anemia · Hemolytic anaemia · Increased hemolysis
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.