Rare diseases · Sign or symptom
Fragile skin
Skin fragility
HP:0001030
What it means
Skin that splits easily with minimal injury.
Rare diseases that can present with this30
Very common80–99%
13- Autosomal dominant generalized epidermolysis bullosa simplex, severe form
- Autosomal recessive generalized dystrophic epidermolysis bullosa, intermediate form
- Autosomal recessive generalized dystrophic epidermolysis bullosa, severe form
- Classical Ehlers-Danlos syndrome
- Congenital erythropoietic porphyria
- Dermatosparaxis Ehlers-Danlos syndrome
- Ectodermal dysplasia-skin fragility syndrome
- Hepatoerythropoietic porphyria
- Kyphoscoliotic Ehlers-Danlos syndrome due to lysyl hydroxylase 1 deficiency
- Localized junctional epidermolysis bullosa
- Porphyria cutanea tarda
- Recessive dystrophic epidermolysis bullosa inversa
- Severe generalized junctional epidermolysis bullosa
Common30–79%
16- Arthrochalasia Ehlers-Danlos syndrome
- Autosomal dominant generalized dystrophic epidermolysis bullosa
- Epidermolysis bullosa simplex with pyloric atresia
- Focal dermal hypoplasia
- Junctional epidermolysis bullosa inversa
- Kyphoscoliotic Ehlers-Danlos syndrome
- Laryngo-onycho-cutaneous syndrome
- Late-onset junctional epidermolysis bullosa
- Lethal acantholytic erosive disorder
- Localized dystrophic epidermolysis bullosa, acral form
- Localized dystrophic epidermolysis bullosa, pretibial form
- Musculocontractural Ehlers-Danlos syndrome
- Necrobiosis lipoidica
- Periodontal Ehlers-Danlos syndrome
- PLEC-related intermediate epidermolysis bullosa simplex without extracutaneous involvement
- Self-improving dystrophic epidermolysis bullosa
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.