Rare diseases · Sign or symptom
Dysphonia
Inability to produce voice sounds
HP:0001618
What it means
Difficulty in speaking due to a physical disorder of the mouth, tongue, throat, or vocal cords. Associated with a known physical or neurological cause.
Rare diseases that can present with this51
Very common80–99%
5Common30–79%
23- Adult-onset cervical dystonia, DYT23 type
- Alexander disease
- Alexander disease type II
- Amyotrophic lateral sclerosis
- Birk-Barel syndrome
- Charcot-Marie-Tooth disease type 4B2
- Dystonia 16
- Hereditary pheochromocytoma-paraganglioma
- Laryngeal neuroendocrine tumor
- Multiple system atrophy, cerebellar type
- Myasthenia gravis
- Neuroferritinopathy
- Niemann-Pick disease type C
- Non-functioning paraganglioma
- Oculopharyngeal muscular dystrophy
- Oromandibular dystonia
- Progressive external ophthalmoplegia-myopathy-emaciation syndrome
- Recurrent respiratory papillomatosis
- Secondary syringomyelia
- Spinocerebellar ataxia type 20
- Sporadic pheochromocytoma/secreting paraganglioma
- Thymoma-hypogammaglobulinemia syndrome
- Worster-Drought syndrome
Sometimes5–29%
23- Adult-onset multiple mitochondrial DNA deletion syndrome due to DGUOK deficiency
- Anaplastic thyroid carcinoma
- Autosomal dominant Charcot-Marie-Tooth disease type 2A2
- Autosomal recessive centronuclear myopathy
- Congenital myasthenic syndrome
- Dermatomyositis
- Distal 22q11.2 microduplication syndrome
- Dystonia 28
and 15 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Voice change
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.