Rare diseases · Sign or symptom
Chromosome breakage
HP:0040012
What it means
Elevated rate of chromosomal breakage or interchanges occurring either spontaneously or following exposure to various DNA-damaging agents. This feature may be assayed by treatment of cultured lymphocytes with agents such as chemical mutagens, irradiation, and alkylating agents.
Part of the broader category
Also called: High frequency of chromosome breaks in lymphocytes · Increased chromosomal breakage · Increased chromosomal breakage rate · Multiple chromosomal breaks · Tendency to chromosomal breakage
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.