Rare diseases · Sign or symptom
Central apnea
HP:0002871
What it means
Apnea resulting from depression of the respiratory centers in the medulla oblongata. There is a lack of respiratory effort rather than obstruction of airflow.
Rare diseases that can present with this20
Common30–79%
8Sometimes5–29%
12- Brachytelephalangic chondrodysplasia punctata
- Classic glucose transporter type 1 deficiency syndrome
- Developmental delay-language impairment-dopa responsive dystonia-parkinsonism syndrome due to 2q24 microdeletion
- Diethylstilbestrol syndrome
- Hereditary sensory and autonomic neuropathy due to TECPR2 mutation
- Infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome
- Lobar holoprosencephaly
- Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
and 4 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Central apnoea
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.