Rare diseases · Sign or symptom
Almond-shaped palpebral fissure
Almond shaped eyes
HP:0007874
What it means
A shape created by an acute downward arching of the upper eyelid and upward arching of the lower eyelid, toward the medial canthus, which gives the outline of the palpebral fissures the configuration of an almond. Thus, the maximum distance between the fissures is offset from, and medial to, the center point.
The almond configuration tends to dissipate with time, as the surrounding tissues (e.g., eyelid, nasal bridge) grow.
Rare diseases that can present with this19
Common30–79%
9- 6q16microdeletion syndrome
- Fanconi anemia
- Frontonasal dysplasia-bifid nose-upper limb anomalies syndrome
- Intellectual disability-autism-speech apraxia-craniofacial dysmorphism syndrome
- MYT1L-related developmental delay-intellectual disability-obesity syndrome
- Prader-Willi syndrome due to paternal 15q11q13 deletion
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 1
- Prader-Willi syndrome due to paternal deletion of 15q11q13 type 2
- Prader-Willi syndrome due to translocation
Sometimes5–29%
9- 21q22.11q22.12microdeletion syndrome
- Infantile hypotonia-oculomotor anomalies-hyperkinetic movements-developmental delay syndrome
- Intellectual disability-cardiac anomalies-short stature-joint laxity syndrome
- PHIP-related behavioral problems-intellectual disability-obesity-dysmorphic features syndrome
- Prader-Willi syndrome
- Prader-Willi syndrome due to maternal uniparental disomy of chromosome 15
- PURA-related severe neonatal hypotonia-seizures-encephalopathy syndrome
- Schaaf-Yang syndrome
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Almond-shaped opening between the eyelids
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.