Pustular pyoderma gangrenosum

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Pustular pyoderma gangrenosum

ORPHA:538866Clinical subtype

What it is

A rare subtype of pyoderma gangrenosum characterized by multiple painful, sterile pustules with a surrounding erythematous halo, predominantly occurring on the trunk and extensor surfaces of the limbs, and potentially persisting for months. Histopathology shows a dermal neutrophilic infiltrate and subcorneal neutrophilic micropustules. The condition is commonly associated with inflammatory bowel disease.

Key facts

Prevalence
<1 / 1 000 000 (annual incidence, Italy)
Age of onset
Adolescent, Adult, Childhood, Elderly
Inheritance
Multigenic/multifactorial
Classified as
Clinical subtype

Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.

Gene

PTPN6Disease-causing germline mutation(s)

ICD-10 codes

L88filed under a broader ICD-10 category — shared with 7 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Cross-references

MONDO 0035236UMLS C5681317

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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