Polymicrogyria

What it is

A heterogenous group of cerebral cortical malformations characterized by excessive cortical folding and abnormal cortical layering that, depending on its topographic distribution, presents with variable combinations of neurological symptoms of varying severity such as epilepsy, developmental delay, intellectual disability, motor dysfunction (e.g. spasticity), and pseudobulbar palsy.

Key facts

Age of onset

Childhood

Inheritance

Autosomal dominant, Autosomal recessive, Not applicable, X-linked dominant

Classified as

Clinical group

Cross-references