Perrault syndrome type 1

Caring for someone with this diagnosis? Eleplan keeps diagnoses, medications, documents and every specialist in one plan.

Start free with Eleplan

Perrault syndrome type 1

ORPHA:642945Clinical subtype

Also called XX gonadal dysgenesis-deafness syndrome-without neurological manifestations

What it is

A form of Perrault syndrome characterized by sensorineural hearing loss and ovarian dysgenesis in females. No neurological features are observed. Hearing loss is sensorineural, generally bilateral, prelingual, progressive, sometimes asymmetric and manifests with variable severity (mild to profound). Majority of the cases have primary amenorrhea.

Key facts

Inheritance
Autosomal recessive
Classified as
Clinical subtype

Recorded for the broader condition

Prevalence
<1 / 1 000 000Perrault syndrome
Age of onset
Adolescent, Adult, ChildhoodPerrault syndrome

Orphanet records these for the broader condition rather than for this specific form. They are a starting point, not a figure for this subtype — subtypes often differ, and some are defined by being rarer than the condition they sit under.

Genes

CLPPDisease-causing germline mutation(s)
DAP3Disease-causing germline mutation(s)
ERAL1Disease-causing germline mutation(s)
GGPS1Disease-causing germline mutation(s)
HARS2Disease-causing germline mutation(s)
HSD17B4Disease-causing germline mutation(s)
LARS2Disease-causing germline mutation(s)
PRORPDisease-causing germline mutation(s) (loss of function)
RMND1Disease-causing germline mutation(s)
TWNKDisease-causing germline mutation(s)

Cross-references

MONDO 0009300OMIM 621101UMLS C5816798

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

Powered by Eleplan

A rare diagnosis is just the start. Eleplan keeps the whole care plan in one place.

Diagnoses, medications, documents, appointments, and the whole care team — organized and always in sync, so you are not retelling the same story to every new specialist. With Ellie, your AI care assistant, on top of it. Free to start.