Mixed cryoglobulinemia type II

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Mixed cryoglobulinemia type II

ORPHA:93554Etiological subtype

Also called MC type II

What it is

A clinico-serological subtype of mixed cryoglobulinemia syndrome, an immune complex disorder, characterized by purpura, weakness and arthralgia and defined immunochemically by cryoglobulins composed of polyclonal IgGs (autoantigens) and monoclonal IgM (autoantibody).

Key facts

Age of onset
All ages
Classified as
Etiological subtype

Recorded for the broader condition

Prevalence
1-9 / 100 000 (United States)Cryoglobulinemic vasculitis
Inheritance
Not applicableCryoglobulinemic vasculitis

Orphanet records these for the broader condition rather than for this specific form. They are a starting point, not a figure for this subtype — subtypes often differ, and some are defined by being rarer than the condition they sit under.

ICD-10 codes

D89.1filed under a broader ICD-10 category — shared with 3 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

MONDO 0019726UMLS C5680264

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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