Leukocyte adhesion deficiency type I

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Leukocyte adhesion deficiency type I

ORPHA:99842Clinical subtype

Also called LAD-I

What it is

A form of leukocyte adhesion deficiency (LAD) characterized by life-threatening, recurrent bacterial infections, neutrophilia, and delayed detachment of the umbilical cord.

Key facts

Prevalence
1-9 / 1 000 000 (Europe)
Age of onset
Childhood, Infancy
Inheritance
Autosomal recessive
Classified as
Clinical subtype

Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.

Gene

ITGB2Disease-causing germline mutation(s)

ICD-10 codes

D84.8filed under a broader ICD-10 category — shared with 39 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Cross-references

GARD 6893MEDDRA 10090483MESH C535887MONDO 0007293OMIM 116920UMLS C0398738

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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