Hereditary persistence of…

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Hereditary persistence of alpha-fetoprotein

ORPHA:168615Biological anomaly

What it is

Hereditary persistence of alpha-fetoprotein is a benign genetic condition characterized by persistence of high alpha-fetoprotein (AFP) levels throughout life, with no associated clinical disability and thus no need for specific therapy

Key facts

Prevalence
<1 / 1 000 000
Age of onset
Adolescent
Inheritance
Autosomal dominant
Classified as
Biological anomaly

Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.

Gene

AFPDisease-causing germline mutation(s)

ICD-10 codes

R77.2filed under a broader ICD-10 category — shared with 1 other rare disease

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

MONDO 0014425OMIM 615970UMLS C1863080

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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