Familial isolated hypoparathyroidism

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Familial isolated hypoparathyroidism due to impaired PTH secretion

ORPHA:189466Clinical subtype

What it is

A rare genetic endocrine disease characterized by impaired secretion of the parathyroid hormone (PTH) by the parathyroid glands not causing other endocrine or developmental disturbances. Complications include impaired renal function, psychomotor and growth delay, delayed dentition, and cataracts.

Key facts

Inheritance
Autosomal dominant, Autosomal recessive
Classified as
Clinical subtype

Recorded for the broader condition

Prevalence
<1 / 1 000 000Familial isolated hypoparathyroidism

Orphanet records these for the broader condition rather than for this specific form. They are a starting point, not a figure for this subtype — subtypes often differ, and some are defined by being rarer than the condition they sit under.

Genes

AIREDisease-causing germline mutation(s)
PTHDisease-causing germline mutation(s)

ICD-10 codes

E20.8filed under a broader ICD-10 category — shared with 5 other rare diseases

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

MONDO 0016000OMIM 146200UMLS C5680524

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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