Familial advanced sleep-phase syndrome

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Familial advanced sleep-phase syndrome

ORPHA:164736Disease

Also called FASPS

What it is

A rare genetic neurological disorder characterized by very early sleep onset and offset. Plasma melatonin levels and body core temperature rhythms are also phase-advanced. The sleep-wake cycle is generally shortened. Additional reported features include migraine with or without aura and seasonal affective disorder.

Key facts

Age of onset
Adolescent, Childhood
Inheritance
Autosomal dominant
Classified as
Disease

Genes

CSNK1DDisease-causing germline mutation(s)
PER2Disease-causing germline mutation(s)
PER3Disease-causing germline mutation(s)

ICD-10 codes

G47.2filed under a broader ICD-10 category — shared with 1 other rare disease

ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.

Related health topics

Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.

Cross-references

GARD 9242MESH C565789MONDO 15609OMIM 604348OMIM 615224OMIM 616882OMIM 620015UMLS C1858496

Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.

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